Transforming Ophthalmology

Focused on developing disruptive ophthalmic solutions to significantly impact patients' lives

Corneal Innervation and Sensitivity

Ocular surface health depends on corneal nerve function, which controls three key protective mechanisms:

1. Blink reflex
2. Tear production
3. Wound healing

Quantitative measurement of corneal sensitivity with non-contact esthesiometry provides key information on corneal nerve function, enabling timely detection of potential ocular surface damage that requires prompt treatment.
Non-contact esthesiometry is the test for screening, early diagnosis, and monitoring of patients at risk for ocular surface disease or neurotrophic damage associated with various conditions, including dry eye disease, long-term use of topical medications (e.g., glaucoma drops), candidates for cataract, refractive, or anterior segment surgery, diabetes, herpes simplex/zoster, and contact lens use.

Product Features

• Non-Contact (noninvasive)
• Portable and designed to be placed on a slit lamp
• Five levels of stimulation: standardized and validated
• Quantifiable method with operator-independent repeatability
• Allows to differentiate 6 different corneal function status: from suspected hypersensitivity to very severe hyposensitivity.
• Electronic precise positioning system
• Includes battery and charging dock
• No consumables required

INSTRUCTIONS FOR USE
*Data on file. Brill 2024.
1.Merayo-Lloves J, et al. Assessment and safety of the newesthesiometer BRILL: Comparison with the Cochet-Bonnet Esthesiometer. Eur J
Ophthalmol. 2024 Jul;34(4):1036-1045. doi: 10.1177/11206721231210754. Epub 2023 Oct 29. PMID: 37899623.
2. Villalba M, Sabates V, Ghalibafan S, Perez V, Swaminathan S, Sabater A. Detection of Subclinical Neurotrophic Keratopathy by Non-Contact Esthesiometry. Res Sq [Preprint]. 2023 May 22:rs.3.rs-2833826. doi:10.21203/rs.3.rs-2833826/v1. Update in: Ophthalmol Ther. 2024
Sep;13(9):2393-2404. doi: 10.1007/s40123-024-00998-9. PMID: 37292809; PMCID:PMC10246231.
3. Surico PL, Yavuz Saricay L, Singh RB, Kahale F, Romano F, Dana R. Corneal Sensitivity and Neuropathy in Patients With Ocular
Graft-Versus-Host Disease. Cornea. 2024 Aug 23. doi:10.1097/ICO.0000000000003680. Epub ahead of print. PMID: 39177407.